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Cosmetic Ingredient Hotlist

Cosmetic Ingredient Hotlist

The Hotlist appears below, listing ingredients in alphabetical order. Substances are designated as prohibited unless a specified restriction is stated. Caution statements and directions for safe use must appear on the label in English. French id available on the Health Canada website.

This list is rather old but it is the most up to date I could find. I will update as soon as a new list is available. We trust that more chemcials will be targeted as the awareness increases and we no longer leave our health in the hands of the cosmetic and drug companies.

  • Acenocoumarol (152-72-7)
  • Acetonitrile (75-05-8)
  • Acetylcholine (β-acetoxyethyl trimethyl ammonium hydroxide) (51-84-3)
  • Acetylsalicylic acid (50-78-2)
  • Aconitine (302-27-2) and its salts
  • Aconitum napellus L. leaves, roots and galenical preparations
  • Adonis vernalis L. and its preparations
  • Alkali earth metal sulfides (including, but not limited to barium sulfide (21109-95-5), calcium sulfide (20548-54-3), magnesium sulfide (12032-36-9), or strontium sulfide (1314-96-1))
    • Permitted at concentrations equal to or less than 6% sulfur in depilatories.
  • Alkali pentacyanonitrosylferrate (2-)
  • Alkali sulfides (including, but not limited to lithium sulfide (12136-58-2), potassium sulfide (1312-73-8), or sodium sulfide (1313-82-2))
    • Permitted at concentrations equal to or less than 2% sulfur in depilatories.
  • O-Alkyldithiocarbonic acids, salts of
  • Alkyne alcohols and their esters, ethers and salts
  • Alloclamide (5486-77-1) and its salts
  • Allyl isothiocyanate (57-06-7)
  • 2-(4-Allyl-2-methoxyphenoxy)-N,N-diethylacetamide (305-13-5) and its salts
  • Alpha-hydroxy acids (including, but not limited to citric acid (77-92-9), glycolic acid (79-14-1), lactic acid (50-21-5), malic acid (6915-15-7), glycolic acid + ammonium glycolate, alpha-hydroxyethanoic acid + ammonium alpha-hydroxyethanoate, alpha-hydroxyoctanoic acid, alpha-hydroxycaprylic acid, hydroxycaprylic acid, mixed fruit acid, triple fruit acid, tri-alpha hydroxy fruit acids, alpha hydroxy and botanical complex, L-alpha hydroxy acid and glycomer in cross-linked fatty acids alpha nutrium)
    • Permitted at concentrations equal to or less than 10%, with a pH equal to or greater than 3.5.
    • Bath bombs may contain levels of citric acid exceeding 10%.
    • Preparations containing higher concentrations of AHAs may be permitted for use if the manufacturer provides Health Canada with evidence of their safety, pH levels, and the directions for use.
    • Cosmetics, with the exception of bath bombs, shall carry cautionary statements to the effect: "Use only as directed, avoid contact with the eyes, if irritation persists, discontinue use and consult a physician, it is recommended that prior to exposure to the sun, users cover areas to which AHAs have been applied, with sunscreen, contact of the product with the skin must be of limited frequency and duration."
  • Ambenonium salts
  • 2-Amino-1,2-bis(4-methoxyphenol) ethanol (530-34-7) and its salts
  • Aminocaproic acid (1319-82-0) and its salts
  • 2-Amino-4-nitrophenol (99-57-0)
  • 2-Amino-5-nitrophenol (121-88-0)
  • 4-Amino-2-nitrophenol (119-34-6)
  • Aminophylline (58-55-9, 317-34-0)
  • 4-Aminosalicylic acid (65-49-6) and its salts
  • Amitriptyline (50-48-6) and its salts
  • Ammi majus and its galenical preparations
  • Amydricaine (alypine) (1,1-bis (dimethylaminomethyl) propyl benzoate) (963-07-5) and its salts
  • Amylocaine (644-26-8) and its salts
  • Anaesthetic effects, substances with
  • Analgesics
  • Anamirta cocculus L. fruit
  • Androgenic effects, substances with
  • Aniline (62-53-3), its salts and, its halogenated and sulfonated derivatives
  • Anthracene (120-12-7) oil
  • Antiandrogens with steroid structure
  • Antibiotics
  • Antihistamines
  • Antimony (7440-36-0) and its compounds
  • Apocynum cannabinum L. and its preparations
  • Apomorphine (58-00-4) and its salts
  • Apronalide (528-92-7)
  • Arecoline (63-75-2)
  • Aristolochic acid (313-67-7) and its salts
  • Arsenic (7440-38-2) and its compounds
  • Atropa belladonna L. and its preparations
  • Atropine (51-55-8), its salts and derivatives
  • Azacyclonol (115-46-8) and its salts
  • Azamethonium salts
  • Barbiturates
  • Barium salts
    • Permitted only as barium sulfate (7727-43-7), as a colouring agent or as a lake for preparation of other colouring agents and barium sulfide (21109-95-5).
  • Basic Violet 1 (CI 42535) (8004-87-3)
  • Basic Violet 3 (CI 42555, CI 42555:1, CI 42555:2) (548-62-9)
  • Basic Violet 10 (CI 45170) (81-88-9)
  • Bemegride (64-65-3)
  • Benactyzine (302-40-9)
  • Bendroflumethiazide (73-48-3) and its derivatives
  • Benzadiazepines
  • Benzalkonium chloride (8001-54-5, 61789-71-7, 68391-01-5, 68424-85-1)
    • Permitted at concentrations equal to or less than 0.1% as a preservative (i.e. benzalkonium chloride with chain lengths ≥14 C) in all products.
    • Permitted at concentrations equal to or less than 3% as a conditioning agent (i.e. benzalkonium chloride with chain lengths ≥16 C) in rinse-off products.
  • Benzatropine (86-13-5) and its salts
  • Benzazepines
  • Benzene (71-43-2)
  • Benzethonium chloride (121-54-0)
    • Permitted at concentrations equal to or less than 0.2% in leave-on products and 0.3% in rinse-off products.
    • Not permitted in products to be applied to mucous membranes.
  • Benzidine (92-87-5)
  • Benzilonium bromide (1050-48-2)
  • Benzimidazol-2(3H)-one
  • Benzoyl peroxide (94-36-0)
    • Permitted at concentrations equal to or less than 10% for use only as a catalyst in products to be applied to the fingernails or in hair dyes.
    • Not permitted in products to be applied to the skin.
  • Benzyl cyanide (140-29-4)
  • Benzylidene acetone (122-57-6)
  • 4-Benzyloxyphenol (monobenzone) (103-16-2)
  • Beryllium (7440-41-7) and its compounds
  • Betoxycaine (3818-62-0) and its salts
  • Bietamiverine (479-81-2)
  • Biphenamine (3572-52-9) and its salts
  • Bispyrithione (3696-28-4)
  • Bithionol (97-18-7)
  • Boric acid (10043-35-3, 11113-50-1) and its salts
    • Permitted at concentrations equal to or less than 5%.
    • The label of the cosmetic shall carry cautionary statements to the effect: "Do not use on broken or abraded skin, not to be used by children under three years of age." Warning is not required when boric acid is used as a pH adjuster and the concentration is equal to or less than 0.1%.
  • Bovine tissues and ingredients derived from the skull, brain, trigeminal ganglia, eyes, spinal cord, and dorsal root ganglia of cattle aged 30 months or older and the small intestine and tonsils of cattle of all ages
    • This prohibition does not apply to tallow derivatives, or to gelatin, collagen and hydrolyzed proteins prepared from bovine hides and skins.
  • Bretylium tosilate (61-75-6)
  • Bromine (7726-95-6), elemental
  • Bromisoval (496-67-3)
  • 2-Bromo-2-nitropropane-1,3-diol (52-51-7)
    • Permitted at concentrations equal to or less than 0.1%.
    • Not permitted in formulations that contain amines or amides.
  • 5-Bromo-5-nitro-1,3-dioxane (30007-47-7)
    • Permitted at concentrations equal to or less than 0.1%.
    • Not permitted in formulations that contain amines or amides.
  • Brompheniramine (86-22-6) and its salts
  • Brucine (357-57-3)
    • Permitted at concentrations equal to or less than 0.1%
  • Butanilicaine (3785-21-5) and its salts
  • Butopiprine (55837-15-5) and its salts
  • Butoxyethanol (111-76-2)
    • Permitted at concentrations equal to or less than 10% in hair dyes and nail products.
  • 1-Butyl-3-(N-crotonoylsulfanilyl) urea (52964-42-8)
  • 4-tert-Butylphenol (98-54-4)
  • 4-tert-Butylpyrocatechol (98-29-3)
  • Cadmium (7440-43-9) and its compounds
  • Calcium peroxide (calcium dioxide) (1305-79-9) (see peroxide and peroxide generating compounds).
  • Camphor (76-22-2)
    • Permitted at concentrations equal to or less than 3%.
  • Cannabis sativa seed oil (Hemp seed oil) (8016-24-8, 68956-68-3)
    • Permitted at concentrations less than 10 μg/g THC (delta-9-tetrahydrocannabinol), as per the Industrial Hemp Regulations.
  • Cantharides
  • Cantharidin (56-25-7)
  • Cantharis vesicatoria
  • Captan (N-(trichloromethylthiol)-4-cyclohexene-1,2-dicarboximide) (133-06-2)
  • Captodiame (486-17-9)
  • Caramiphen (77-22-5, 125-85-9) and its salts
  • Carbamide (urea) peroxide (124-43-6) (see peroxide and peroxide generating compounds).
  • Carbazol (86-74-8), nitroderivatives of
  • Carbon disulfide (75-15-0)
  • Carbon tetrachloride (56-23-5)
  • Carbromal (77-65-6)
  • Carbutamide (339-43-5)
  • Carisoprodol (78-44-4)
  • Catalase (9001-05-2)
    • The inner label and the outer label of the cosmetic shall carry a cautionary statement to the effect: "This product is not intended for use on broken or abraded skin."
  • Cephaeline (483-17-0) and its salts
  • Cephaelis ipecacuanha Brot. and related species roots, powder, and galenical preparations
  • Chenopodium ambrosioides essential oil (8006-99-3)
  • Chloral hydrate (302-17-0)
  • Chloramine T (127-65-1)
  • Chlorhexidine (55-56-1) and its salts
    • Permitted at concentrations equal to or less than 0.14%, calculated as chlorhexidine (55-56-1) free base; 0.19%, calculated as chlorhexidine diacetate (56-95-1); 0.20%, calculated as chlorhexidine digluconate (18472-51-0); and 0.16%, calculated as chlorhexidine dihydrochloride (3697-42-5)
  • Chlorine (7782-50-5)
  • Chlormethine (51-75-2) and its salts
  • Chlormezanone (80-77-3)
  • Chloroacetamide (79-07-2)
  • N-5-Chlorobenzoxazol-2-ylacetamide and its salts
  • Chloroethane (75-00-3)
  • N,N-bis(2-Chloroethyl)methylamine N-oxide and its salts
  • Chloroform (67-66-3)
  • Chlorophacinone (2-(2-4-chlorophenyl)-2-phenylacetyl indan-1,3-dione) (3691-35-8)
  • Chlorphenoxamine (77-38-3)
  • Chlorpropamide (94-20-2)
  • Chlorprothixene (113-59-7) and its salts
  • Chlortalidone (77-36-1)
  • Chlorzoxazone (95-25-0)
  • Cholecalciferol (67-97-0)
    • Average daily absorption must be equal to or less than 25 μg per day.
  • Choline (62-49-7) salts and their esters
  • Chromic acid (1308-14-1, 7738-94-5,13530-68-2) and its salts
  • Chromium (7440-47-2)
  • Chrysoidine citrate hydrochloride
  • CI 12140 (3118-97-6)
  • CI 13065 (587-98-4)
  • CI 42640 (1694-09-3)
  • Cinchocaine (85-79-0) and its salts
  • Cinchophen (132-60-5), its salts, derivatives and salts of these derivatives
  • Citrus reticulata leaf oil (8014-17-3)
    • Permitted at concentrations equal to or less than 0.1% in leave-on products.
  • Claviceps purpurea Tul., its alkaloids and galenical preparations
  • Clobetasone (54063-32-0)
  • Clofenamide (671-95-4)
  • Clofenotane (50-29-3)
  • Clostridium botulinum
  • Coal tar dye, coal tar dye base or coal tar dye intermediate
    • According to section 14 of the Cosmetic Regulations, "no person shall sell a cosmetic for use in the area of the eye that contains any coal tar dye, coal tar dye base or coal tar dye intermediate." "Area of the eye" is defined by the area bound by the supraorbital and infraorbital ridges and includes the eyebrows, the skin underlying the eyebrows, the eyelids, and eyelashes, the conjunctival sac of the eye, the eyeball and the soft tissue that lies below the eye and within the infraorbital ridge.
    • The following coal tar dyes are permitted in the area of the eye: Blue 1 (3844-45-9) and lake, Green 5 (4403-90-1), Red 40 (25956-17-6) and lake, Yellow 5 (1934-21-0) and lake.
    • Permitted in hair dye provided:
      1. the inner label and the outer label of the cosmetic shall carry statements to the effect:

        "CAUTION: this product contains ingredients that may cause skin irritation on certain individuals and a preliminary test according to accompanying directions should first be made. This product must not be used for dying the eyelashes or eyebrows. To do so, may cause blindness."

        "MISE EN GARDE: Ce produit contient des ingrédients qui peuvent causer de l'irritation cutanée chez certaines personnes: il faut donc d'abord effectuer une épreuve préliminaire selon les directives ci-jointes. Ce produit ne doit pas servir à teindre les sourcils ni les cils: en ce faisant, on pourrait provoquer la cécité."; and
      2. instructions to the following effect accompany each package of hair dye:
        1. the preparation may cause serious inflammation of the skin in some persons and a preliminary test should always be carried out to determine whether or not special sensitivity exists; and
        2. to make the test, a small area of skin behind the ear or on the inner surface of the forearm should be cleansed, using either soap and water or alcohol, and a small quantity of the hair dye as prepared for use should be applied to the area and allowed to dry. After 24 hours, the area should be washed gently with soap and water. If no irritation or inflammation is apparent, it is usually assumed that no hypersensitivity to the dye exists. The test should, however, be carried out before each application. On no account should the hair dye be used for dyeing eyebrows or eyelashes as severe inflammation of the eye or even blindness may result.
  • Coal tars (crude and refined) (8007-45-2)
  • Cobalt benzenesulfonate
  • Colchicine (64-86-8), its salts and derivatives
  • Colchicoside (477-29-2) and its derivatives
  • Colchicum autumnale L. and its galenical preparations
  • Coniferyl alcohol (4-hydroxy-3-methoxycinnamyl alcohol) (458-35-5), except for naturally occuring in plant extracts.
  • Coniine (458-88-8)
  • Conium maculatum L. fruit, powder and galenical preparations
  • Convallatoxin (508-75-8)
  • Coumetarol (4366-18-1)
  • Creosote (coal tar creosote (8001-58-9), wood creosote (8029-39-4))
  • Crimidine (2-chloro-6-methylpyrimidin-4-yldimethylamine) (535-89-7)
  • Croton tiglium oil (8001-28-3)
  • Curare (8063-06-7, 2251-14-9)
  • Curarine (22260-42-0)
  • Curarizants, synthetic
  • Cyclarbamate (5779-54-4)
  • Cyclizine (82-92-8) and its salts
  • Cyclocoumarol (518-20-7)
  • Cyclomenol (5591-47-9) and its salts
  • Cyclophosphamide (50-18-0) and its salts
  • Datura stramonium L. and its galenical preparations
  • Deanol aceglumate (3342-61-8)
  • Decamethylenebis (trimethylammonium) salts
  • Dextromethorphan (125-71-3) and its salts
  • Dextropropoxyphene (469-62-5)
  • O,O'-Diacetyl-N-allyl-N-normorphine
  • Dialkanolamines, secondary
  • 2,4-Diaminophenylethanol and its salts
  • 5-(α, β-Dibromophenethyl)-5-methylhydantoin (511-75-1)
  • Dibromosalicylanilides
  • Dichloroethanes (ethylene chlorides)
  • Dichloroethylenes (acetylene chlorides)
  • 2,3-Dichloro-2-methylbutane (507-45-9)
  • Dichlorosalicylanilides
  • Dicoumarol (66-76-2)
  • 3-Diethylaminopropyl cinnamate
  • Diethyl maleate (141-05-9)
  • Diethyl 4-nitrophenyl phosphate (311-45-5)
  • Diethyl toluamide (DEET) (134-62-3)
  • Difencloxazine (5617-26-5)
  • Digitaline (71-63-6)
  • Digitalis purpurea L., all heterosides of
  • Dihydrocoumarin (119-84-6)
  • Dihydrotachysterol (67-96-9)
  • 2,4-Dihydroxy-3-methylbenzaldehyde (6248-20-0)
  • 4,4'-Dihydroxy-3,3'-(3-methylthiopropylidene) dicoumarin
  • 5,5'-Diisopropyl-2,2'-dimethylbiphenyl-4,4'-diyl dihypoiodite
  • Dimethoxane (2,6-dimethyl-1,3-dioxan-4-yl acetate) (828-00-2)
  • Dimethylamine (124-40-3)
  • 4,6-Dimethyl-8-tert-butylcoumarin (17874-34-9)
  • Dimethyl citraconate (617-54-9)
  • 7,11-Dimethyl-4,6,10-dodecatrien-3-one (26651-96-7)
    • Permitted at concentrations equal to or less than 2% only as an impurity in methylionones.
  • Dimethylformamide (68-12-2)
  • 1,3-Dimethylpentylamine (105-41-9) and its salts
  • Dimethyl sulfoxide (DMSO) (67-68-5)
  • 6,10-Dimethyl-3,5,9-undecatrien-2-one (141-10-6)
  • Dimevamide (60-46-8) and its salts
  • Dinitrophenol isomers (25550-58-7)
  • Dioxane (1,4-dioxane) (123-91-1)
  • Dioxethedrin (497-75-6) and its salts
  • Diphenhydramine (58-73-1) and its salts
  • Diphenoxylate hydrochloride (3810-80-8)
  • Diphenylamine (122-39-4)
  • 5,5-Diphenyl-4-imidazolidone (3254-93-1)
  • Diphenylpyraline (147-20-6) and its salts
  • Disulfiram (97-77-8)
  • Doxylamine (469-21-6) and its salts
  • Emetine (483-18-1), its salts and derivatives
  • Endrin (72-20-8)
  • Ephedrine (299-42-3) and its salts
  • Epinephrine (51-43-4)
  • 1,2-Epoxybutane (106-88-7)
  • Ergocalciferol (50-14-6)
    • Average daily absorption should be equal to or less than 25 μg per day.
  • Eserine (57-47-6) and its salts
  • Estil (305-13-5) and its salts
  • Estradiol (50-28-2)
  • Estrogens
  • Estrone (53-16-7)
  • Ethinylestradiol (57-63-6)
  • Ethionamide (536-33-4)
  • Ethoheptazine (77-15-6) and its salts
  • Ethoxyethanol (110-80-5)
  • Ethoxyethanol acetate (111-15-9)
  • 4-Ethoxyphenol (622-62-8)
  • 4-Ethoxy-m-phenylenediamine (5862-77-1) and its salts
  • Ethyl biscoumacetate (548-00-5) and salts of the acid
  • Ethylenediamine (107-15-3)
  • Ethylene oxide (75-21-8)
  • Ethyl methacrylate (97-63-2)
    • The label of the cosmetic shall carry a cautionary statement to the effect: "Avoid skin contact".
  • Ethyl PABA (benzocaine) (94-09-7)
  • Ethylphenacemide (90-49-3)
  • β-Eucaine (500-34-5)
  • Eucalyptus oil (8000-48-4)
    • Permitted at concentrations equal to or less than 25%.
  • Fenadiazole (1008-65-7)
  • Fenozolone (15302-16-6)
  • Fenyramidol (553-69-5)
  • Ficus carica leaf absolute (68916-52-9)
  • Fluanisone (1480-19-9)
  • Fluoresone (2924-67-6)
  • Fluoride (16984-48-8) containing substances (including, but not limited to sodium fluoride (1333-83-1, 7681-49-4), calcium fluoride (7789-75-5), stannous fluoride (7783-47-3) and sodium monofluorophosphate (10163-15-2))
    • Not permitted in dentifrices, mouthwashes or breath drops.
  • Fluorouracil (51-21-8)
  • Formaldehyde (50-00-0)
    • Permitted at concentrations equal to or less than 0.2% as the minimum concentration to provide effective antimicrobial preservation, except in nail hardeners where the concentration can be equal to or less than 5% and in oral care products where concentrations are equal to or less than 0.1%.
    • Nail hardeners containing formaldehyde must be sold with nail shields, directions for use, and a cautionary statement to the effect: "This product contains formaldehyde which has the potential to cause skin sensitivity".
    • Not permitted in aerosol cosmetics.
  • Furazolidone (67-45-8)
  • Furfuryltrimethylammonium salts
  • Furocoumarins (66-97-7), except for naturally occurring in plant extracts
    • Permitted at concentrations less than 1 mg/kg in sun tanning products.
  • Galantamine (357-70-0)
  • Gallamine triethiodide (65-29-2)
  • Glucocorticoids (1524-88-5)
  • Glutarimide (1121-89-7) and its salts
  • Glutethimide (77-21-4) and its salts
  • Glycyclamide (664-95-9)
  • Gold salts
  • Guaifenesin (93-14-1)
  • Guanethidine (55-65-2) and its salts
  • Haloperidol (52-86-8)
  • trans-2-Heptenal (18829-55-5)
  • Hexachloroethane (67-72-1)
  • Hexachlorophene (2,2'-dihydroxy-3,3',5,5'6,6'-hexachlorodiphenylmethane) (70-30-4)
  • Hexaethyl tetraphosphate (757-58-4)
  • Hexamethonium salts
  • Hexapropymate (358-52-1)
  • Human origin, substance of (including, but not limited to human placental extracts, human placental enzymes, human placental lipids, human placental protein, human umbilical extract, hydrolyzed human placental protein (73049-73-7), hydrolyzed keratin from human hair, lyophilized human placental extract)
    • Manufacturers using substances of human origin must provide the following information to the Cosmetics Division of the Consumer Product Safety Bureau:
      1. source of the substance;
      2. a description of the method of production;
      3. quality control data, particularly those relating to microbial limits (including viruses) and the absence of estrogenic substances;
      4. product labelling.
  • Hydrastine (118-08-1) and their salts
  • Hydrastinine (6592-85-4) and their salts
  • Hydrazides and their salts
  • Hydrazine (302-01-2), its derivatives and their salts
  • Hydroabietyl alcohol (13393-93-6)
  • Hydrofluoric acid (7664-39-3), its normal salts, its complexes and hydrofluorides
  • Hydrogen cyanide (74-90-8) and its salts
  • Hydrogen peroxide (7722-84-1) (see peroxide and peroxide generating compounds).
  • Hydrolyzed Hemp seed protein
    • Permitted at concentrations less than 10 μg/g THC (delta-9-tetrahydrocannabinol), as per the Industrial Hemp Regulations.
  • Hydroquinone (123-31-9)
    • Not permitted in products to be applied on the skin or mucous membranes.
  • p-Hydroxyanisole (4-methoxyphenol) (150-76-5)
    • Permitted at concentrations equal to or less than 0.02% (after mixing), for professional use only, in artificial nail systems.
    • The inner label and the outer label of the cosmetic shall carry statements to the effect: "For professional use only, avoid skin contact, read use directions carefully".
  • 11-α-Hydroxypregn-4-ene-3,20-dione (80-75-1) and its esters
  • 8-Hydroxyquinoline (148-24-3) and its sulfate (134-31-6)
    • Permited at concentrations equal to or less than 0.3% as stabilizers for hydrogen peroxide in rinse-off hair-care preparations, and 0.03% in leave-on preparations.
  • Hydroxyzine (68-88-2)
  • Hyoscine (51-34-3), its salts and derivatives
  • Hyoscyamine (101-31-5), its salts and derivatives
  • Hyoscyamus niger L. leaves, seeds, powder, and galenical preparations
  • 3-Imidazol-4-ylacrylic acid (104-98-3) and its ethyl ester (urocanic acid (108-98-3))
  • Imperatorin (482-44-0)
  • Indanedioxa
    • Permitted as a fragrance ingredient, as per the Canadian Environmental Protection Act's Ministerial Condition No. 13052, September 4, 2004.
  • Inproquone (436-40-8)
  • Inula helenium oil (97676-35-2)
  • Iodine (7553-56-2)
  • Isocarboxazide (59-63-2)
  • Isodrin (465-73-6)
  • Isometheptene (503-01-5) and its salts
  • Isophorone (78-59-1)
  • Isoprenaline (7683-59-2)
  • Isopropamide (N-(3-carbamoyl-3,3-diphenylpropyl)-N,N-diisopropylmethylammonium) salts
  • 6-Isopropyl-2-decahydronaphthalenol (34131-99-2)
  • Isosorbide dinitrate (87-33-2)
  • Juniperus sabina L. leaves, essential oil (68916-94-9) and galenical preparations
  • Keratin (see Human origin, substances of and/or Bovine tissues and ingredients)
  • Laurus nobilis L., oil (8007-48-5) from the seeds of
  • Lead (7439-92-1) and its compounds
  • Lead acetate (301-04-2)
  • Levophacetoperane (24558-01-8) and its salts
  • Lidocaine (137-58-6)
  • Lindane (58-89-9)
  • Lobelia inflata L. and its galenical preparations
  • Lobeline (90-69-7) and its salts
  • Lysergide (50-37-3) and its salts
     
  • Magnesium peroxide (1335-26-8) (see peroxide and peroxide generating compounds).
  • Malononitrile (109-77-3)
  • Mannomustine (576-68-1) and its salts
  • Mecamylamine (60-40-2)
  • Mefeclorazine (1243-33-0) and its salts
  • Mephenesin (59-47-2) and its esters
  • Meprobamate (57-53-4)
  • Mercury (7439-97-6) and its compounds (including, but not limited to mercuric oxide (21908-53-2), phenyl mercuric acetate (62-38-4), phenyl mercuric benzoate (94-43-9), phenyl mercuric borate (102-98-7, 6273-99-0) and thimerosal (54-64-8))
  • Mescaline (3,4,5-trimethoxyphenethylamine) (54-04-6) and its salts
  • Metaldehyde (9002-91-9)
  • Metamfepramone (15351-09-4) and its salts
  • Metethoheptazine (509-84-2) and its salts
  • Metformin (657-24-9) and its salts
  • Methacrylic acid (79-41-4)
    • The inner label and the outer label of a cosmetic that contains more than 5% methacrylic acid shall carry a cautionary statement to the effect: "This product contains methacrylic acid, is poisonous, is to be kept out of reach of children and, in the case of accidental ingestion, a Poison Control Centre or physician is to be contacted immediately".
  • Methapyrilene (91-80-5) and its salts
  • Metheptazine (469-78-3) and its salts
  • Methocarbamol (532-03-6)
  • Methotrexate (59-05-2)
  • 2-(-4-Methoxybenzyl-N-(2-pyridyl)amino) ethyldimethylamine maleate
  • 7-Methoxycoumarin (531-59-9)
  • 1-Methoxy-2,4-diaminobenzene (2,4-diaminoanisole, Cl 76050) (615-05-4) and their salts
  • 1-Methoxy-2,5-diaminobenzene (2,5-diaminoanisole) (1244-42-1) and their salts
  • Methoxyethanol (109-86-4)
  • 4-(4-Methoxyphenyl)-3-butene-2-one (943-88-4)
  • 4-Methoxy-m-phenylenediamine (615-05-4) and its sulfate salts
  • 4-Methoxy-m-phenylenediamine-HCl
  • Methyl alcohol (67-56-1)
    • The principal display panel of the inner label and the outer label of the container of a cosmetic, other than a disposal metal container designed to release pressurized contents by the use of a manually operated valve that forms an integral part of the container, that contains an amount of methyl alcohol equal or greater than 5 mL, shall display:
      1. the hazard symbol set out in column II of item 1 of Schedule II of the Consumer Chemicals and Containers Regulations, as they read on September 30th, 2001, in accordance with paragraphs 16(a) and (b) of those regulations; and
      2. for each of the particulars set out in column 1 of items 1 to 5 of the Consumer Chemicals and Containers Regulations, the signal word and statements set out in column III and IV of those items which shall be located on the labels in accordance with paragraphs 15(2)(a) to (c) of those regulations and printed in accordance with paragraphs 17(a) and (b), 18(a), (b) and 19(1)(a) and (b) and subsection 19(2) of those regulations.
  • α-Methylanisalacetone (104-27-8)
  • Methyl-trans-2-butenoate (623-43-8)
  • Methylene chloride (75-09-2)
    • Not permitted in aerosol preparations.
  • Methyl eugenol (93-15-2)
    • Permitted as a naturally occuring component in botanical extracts at concentrations equal to or less than 0.01% in fine fragrances, 0.004% in eau de toilette, 0.002% in a fragrance cream, 0.0002% in other leave-on products and in oral hygiene products, and 0.001% in rinse-off products.
  • 2-Methylheptylamine (540-43-2) and its salts
  • 5-Methyl-2,3-hexanedione (13706-86-0)
  • Methylisothiazolinone (2682-20-4)/ Methylchloroisothiazolinone (26172-55-4), in combination
    • Permitted at concentrations equal to or less than 0.0015% (15 μg/mL or 15 ppm) in rinse-off products and 0.00075% (7.5 μg/mL or 7.5 ppm) in leave-on products.
  • Methylisothiazolinone (2682-20-4)
    • Permitted at concentrations equal to or less than 0.01% for use as a preservative.
  • Methyl methacrylate monomer (80-62-6)
  • Methyl N-methyl anthranilate (85-91-6)
    • Permitted at concentrations equal to or less than 0.1%.
  • Methylphenidate (113-45-1) and its salts
  • 2-Methyl-m-phenylenediamine (823-40-5)
  • 4-Methyl-m-phenylenediamine (95-80-7) and its salts
  • Methyl salicylate (119-36-8)
    • Permitted at concentrations equal to or less than 1%.
  • Methyprylon (125-64-4) and its salts
  • Metyrapone (54-36-4)
  • Minoxidil (38304-91-5), its salts and derivatives
  • Mixed cresols (1319-77-3) and derivatives
  • Mofebutazone (2210-63-1)
  • Morpholine (110-91-8) and its salts
  • Musk ambrette (4-tert-butyl-3-methoxy-2,6-dinitrotoluene) (83-66-9)
  • Musk tibetene (5-tert-butyl-1,2,3-trimethyl-4,6-dinitrobenzene) (145-39-1)
  • Nail adhesives that have the capability to quickly bond skin
    • The innermost package, sold alone or as part of a kit, must be child resistant. Refer to part 4 of the Consumer Chemicals and Containers Regulations as they read on September 30th, 2001 for requirements.
  • Nalorphine (62-67-9), its salts and ethers
  • Naphazoline (835-31-4) and its salts
  • 2-Naphthol (135-19-3)
  • 1-and 2-Naphthylamines (134-32-7 and 91-59-8, respectively) and their salts
  • 3-(α-Naphthyl)-4-hydroxycoumarin (39923-41-6)
  • Narcotics, natural and synthetic
  • Neodymium (7440-00-8) and its salts
  • Neostigmine (59-99-4) and its salts
  • Nicotine (54-11-5) and its salts
  • Nitrites, amyl
  • Nitrites (14797-65-0), inorganic, except sodium nitrite
  • Nitrobenzene (98-95-3)
  • Nitrocresols (12167-20-3) and their alkali metal salts
  • Nitrofurantoin (67-20-9)
  • Nitroglycerin (55-63-0)
  • Nitrosamines
  • Nitrostilbenes, their homologues and their derivatives
  • Nitroxoline (4008-48-4) and its salts
  • Noradrenaline (51-41-2) and its salts
  • Noscapine (128-62-1) and its salts
  • Octamoxin (4684-87-1) and its salts
  • Octamylamine (502-59-0) and its salts
  • Octodrine (543-82-8) and its salts
  • Oleandrin (465-16-7)
  • Oxanamide (126-93-2) and its derivatives
  • Oxypheneridine (546-32-7) and its salts
  • PABA (4-aminobenzoic acid), esters of; with a free amino group
  • Paramethasone (53-33-8)
  • Parathion (O,O'-diethyl O-4-nitrophenyl phosphorothioate) (56-38-2)
  • Parethoxycaine (94-23-5) and its salts
  • Pelletierine (2858-66-4) and its salts
  • Pemoline (2152-34-3) and its salts
  • Pentachloroethane (76-01-7)
  • Pentaerythrityl tetranitrate (78-11-5)
  • Pentamethonium salts
  • Pentyl dimethyl PABA (14779-78-3) (amyl 4-dimethylaminobenzoate), mixed isomers
  • 2-Pentylidenecyclohexanone (25677-40-1)
  • Peroxide and peroxide-generating compounds (including, but not limited to urea (carbamide) peroxide (124-43-6), calcium peroxide (calcium dioxide) (1305-79-9), hydrogen peroxide (7722-84-1), magnesium peroxide (1335-26-8), sodium perborate (7632-04-4), and zinc peroxide (1314-22-3).
    • The labels of oral cosmetics containing peroxides or peroxide generating compounds shall carry cautionary statements to the effect:
      • "If irritation (such as redness, swelling, soreness) of the gums or the mouth occurs, discontinue use and consult a dentist, products containing peroxides are not recommended for use by children under 12 years of age, use for periods of longer than 14 days is to be only under the supervision of a dentist, avoid swallowing the cosmetic or part thereof and, avoid contact of the product with the eye".
    • Tooth whitening system cosmetics shall carry an additional cautionary statement to the effect: "Avoid direct contact of the active surface of the tooth whitening product with the gums and/or salivary flow."
    • Manufacturers of oral products containing peroxides or peroxide-generating compounds must submit the following information to the Cosmetics Division of the Consumer Product Safety Bureau:
      1. data on the pH of the cosmetic product, when it is applied to the tooth or teeth, to ensure that the product is in compliance with section 13 of the Cosmetic Regulations, i.e. that the pH is greater than or equal to 4.0; and
      2. product labelling demonstrating that all warning/cautionary statement requirements have been met.
    • If an oral cosmetic contains more than 3% hydrogen peroxide (or equivalent), notifiers must submit evidence that the product does not cause the saliva or soft tissue of the oral cavity to exceed 3% hydrogen peroxide, and is safe when used as directed. Evidence may include analog studies from recognized sources or independent clinical research.
    • NB:
      Please be aware of the conversion factor between hydrogen peroxide and other peroxide-generating compounds. For example, 10% carbamide (urea) peroxide is approximately equivalent to 3% hydrogen peroxide.
  • Petrichloral (78-12-6)
  • Phenacemide (63-98-9)
  • Phenaglycodol (79-93-6)
  • Phenetamine (3590-16-7)
  • Phenindione (83-12-5)
  • Phenmetrazine (134-49-6), its derivatives and salts
  • Phenol (108-95-2)
  • Phenolphthalein (77-09-8)
  • Phenothiazine (92-84-2) and its compounds
  • Phenprobamate (673-31-4)
  • Phenprocoumon (435-97-2)
  • Phenylbutazone (50-33-9)
  • o-Phenylenediamine (95-54-5) and its salts
  • p-Phenylenediamine (106-50-3)
    • Permitted only in oxidative hair dyes provided:
      1. the inner label and the outer label of the cosmetic products carry the following warning:
        • "CAUTION: This product contains ingredients that may cause skin irritation on certain individuals and a preliminary test according to accompanying directions should first be made. This product must not be used for dying the eyelashes or eyebrows. To do so, may cause blindness.
        • MISE EN GARDE: Ce produit contient des ingrédients qui peuvent causer de l'irritation cutanée chez certaines personnes: il faut donc d'abord effectuer une épreuve préliminaire selon les directives ci-jointes. Ce produit ne doit pas servir à teindre les sourcils ni les cils: en ce faisant, on pourrait provoquer la cécité.", and
      2. instructions to the following effect accompany each package of hair dye:
        1. the preparation may cause serious inflammation of the skin in some persons and a preliminary test should always be carried out to determine whether or not special sensitivity exists; and
        2. to make the test, a small area of skin behind the ear or on the inner surface of the forearm should be cleansed, using either soap and water or alcohol, and a small quantity of the hair dye as prepared for use should be applied to the area and allowed to dry. After 24 hours, the area should be washed gently with soap and water. If no irritation or inflammation is apparent, it is usually assumed that no hypersensitivity to the dye exists. The test should, however, be carried out before each application. On no account should the hair dye be used for dyeing eyebrows or eyelashes as severe inflammation of the eye or even blindness may result.
    • Not permitted in products intended for use on the skin.
  • Pheromones
  • Phosphorus (7723-14-0) and metal phosphides
  • Physostigma venenosum Balf.
  • Phytolacca spp. and their preparations
  • Picric acid (88-89-1)
  • Picrotoxin (124-87-8)
  • Pigment Orange 5 (CI 12075) (3468-63-1) and its lakes, pigments and salts
  • Pigment Red 53 (CI 15585) (2092-56-0)
  • Pilocarpine (92-13-7) and its salts
  • Pilocarpus jaborandi Holmes and its galenical preparations
  • Pipazetate (2167-85-3) and its salts
  • Piper methysticum extract (kava kava) (9000-38-8)
  • Pipradrol (467-60-7) and its salts
  • Piprocurarium salts
  • Placental extracts (see Human origin, substances of )
  • Poldine methylsulfate (545-80-2)
  • Potassium bromate (2139-59-4)
    • The inner label and the outer label of a cosmetic that contains an amount of potassium bromate equal to or greater than 50 mg shall carry a cautionary statement to the effect: "This product contains potassium bromate, is poisonous, and is to be kept out of the reach of children and, in case of accidental ingestion, a Poison Control Centre or physician is to be contacted immediately."
    • Cosmetics containing potassium bromate must be packaged in a child-resistant container, according to part 4 of the Consumer Chemicals and Containers Regulations as they read on September 30th, 2001.
  • Pramocaine (140-65-8)
  • Probenecid (57-66-9)
  • Procainamide (51-06-9), its salts and derivatives
  • Progestogens
  • Propatylnitrate (2921-92-8)
  • Propyphenazone (479-92-5)
  • Prunus laurocerasus L.
  • Psilocybine (520-52-5)
  • Pueraria mirifica
  • Pyrethrum album L. and its galenical preparations
  • Pyrocatechol (catechol) (120-80-9)
  • Pyrogallol (87-66-1)
     
  • Radioactive substances
  • Rauwolfia serpentina alkaloids and their salts
  • Retinol (vitamin A) (68-26-8) and its esters; retinyl acetate (127-47-9), retinyl palmitate (79-81-2)
    • Permitted at concentrations equal to or less than 1%.
  • Safrole (94-59-7) except when naturally occurring in plant extracts
  • Salicylic acid (69-72-7)
    • Permitted at concentrations equal to or less than 2%.
  • α-Santonin (481-06-1)
  • Schoenocaulon officinale Lind. seeds and galenical preparations
  • Selenium (7782-49-2) and its compounds, excluding selenium sulfide (7488-56-4).
  • Siloxanes and Silicones, 3-[(2-aminoethyl)amino]-2-methylpropyl Me, di-Me, reaction products with N,N,N-trimethyloxiranemethanaminium chloride (495403-02-6),
    • For concentrations exceeding 4%, the company must submit a skin sensitization study and other data requirements to Environment Canada's New Substances Program at least 90 days prior to the manufacture of the product, as per Significant New Activity Notice No. EAU-135 under the Canadian Environmental Protection Act's New Substances Notification Regulations, November 13, 2004.
  • Silver (7440-22-4) and its salts
    • Restricted to concentrations equal to or less than 0.04% in mouthwash.
    • Any cosmetic containing silver and/or its salts shall carry cautionary statements to the effect: "This product contains silver and/ or silver salts, avoid contact with broken or abraded skin."
  • Sodium borate (1303-96-4)
    • Permitted at concentrations equal to or less than 5%.
    • The label of the cosmetic shall carry cautionary statements to the effect: "Do not use on broken or abraded skin, not to be used by children under three years of age." Warnings are not required where sodium borate is used as a pH adjuster, and the concentration is equal to or less than 0.1%.
  • Sodium bromate (7789-38-0)
    • The inner label and the outer label of a cosmetic that contains an amount of sodium bromate equal to or greater than 600 mg shall carry a cautionary statement to the effect: "This product contains sodium bromate, is poisonous, is to be kept out of the reach of children and, in case of accidental ingestion, a Poison Control Centre or physician is to be contacted immediately."
    • Cosmetics containing sodium bromate must be packaged in a child-resistant container, according to part 4 of the Consumer Chemicals and Containers Regulations as they read on September 30th, 2001.
  • Sodium hexacyclonate (7009-49-6)
  • Sodium perborate (7632-04-4) (see peroxide and peroxide generating compounds).
  • Sodium picramate (831-52-7)
    • Permitted at concentrations equal to or less than 0.1%
  • Sodium pyrithione (3811-73-2)
  • Solanum nigrum L. and its galenical preparations
  • Solvent Blue 35 (CI 61554) (17354-14-2)
  • Solvent Red 24 (CI 26105) (85-83-6)
  • Solvent Red 49:1 (Cl 45170-1) (81-88-9)
  • Sparteine (90-39-1) and its salts
  • Spironolactone (19-00-0)
  • Steroids
  • Strontium (7440-24-6) and its salts, other than nitrite
    • Permitted at concentrations equal to or less than 6.6% in salt, or equal to or less than 2.1% elemental strontium, whichever represents the smallest amount of strontium (depending on the salt).
    • Permitted at concentrations equal to or less than 3.5% strontium in depilatory products.
    • Not permitted in aerosol products.
  • Strontium nitrite (13470-06-9)
  • Strontium polycarboxylate
  • Strophantines, their aglucones and derivatives
  • Strophantus spp. and their galenical preparations
  • Strychnine (57-24-9) and its salts
  • Strychnos spp. and their galenical preparations
  • Succinonitrile (110-61-2)
  • Sulfinpyrazone (57-97-5)
  • Sulfonamides (63-74-1) and their salts obtained by substitution of one or more H-atoms of the -NH2 groups
  • Sultiame (61-56-3)
  • Sympathicomimetic amines
  • Symphytum spp. (Comfrey), with the exception of Symphytum officinale
  • Tagetes oil (8016-84-0) and absolute
    • Permitted at concentrations equal to or less than 0.01% in leave-on products.
  • Talc
    • The inner label and the outer label of baby powder products shall carry cautionary statements to the effect: "Keep out of reach of children, and keep powder away from child's face to avoid inhalation which can cause breathing problems."
  • TBHQ (t-butylhydroquinone) (1948-33-0)
    • Permitted at concentrations equal to or less than 0.1%.
  • Tefazoline (1082-56-0) and its salts
  • Tellurium (13494-80-9) and its compounds
  • Tetrabenazine (58-46-8) and its salts
  • Tetrabromosalicylanilides
  • Tetracaine (94-24-6) and its salts
  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6)
  • Tetrachloroethylene (127-18-4)
  • Tetrachlorosalicylanilides
  • Tetraethyl pyrophosphate (107-49-3)
  • Tetrahydrozoline (84-22-0) and its salts
  • Tetrylammonium bromide (71-91-0)
  • Thalidomide (50-35-1) and its salts
  • Thallium (7440-28-0) and its compounds
  • Theophylline (58-55-9)
  • Thevetia nerifolia Juss. glycoside extract
  • Thiamazole (60-56-0)
  • Thimerosal (54-64-8) (see mercury and its compounds)
  • Thioglycolic acid (68-11-1) and its salts
    • Permitted at concentrations equal to or less than 8% with a pH of 7 to 9.5 in hair waving and straightening products.
      • Directions for use shall carry cautionary statements to the effect: "Avoid direct skin contact, wear suitable gloves".
    • Permitted at concentrations equal to or less than 11% with a pH of 7 to 9.5 in hair waving and straightening products for professional use.
      • The label of the cosmetic shall carry, in addition to the above directions, a statement to the effect: "For professional use only".
    • Permitted at concentrations equal to or less than 5% with a pH of 7 to 12.7 in depilatory products.
      • The label of the cosmetic shall carry cautionary statements to the effect: "Avoid contact with eyes and, in the event of contact with eyes, rinse immediately with plenty of water and seek medical attention".
  • Thiotepa (52-24-4)
  • Thiourea (62-56-6) and its derivatives, with the exception of thioglycolic acid and its salts and esters
  • Thiuram (137-26-8)
  • Thiuram disulfides
  • Thiuram monosulfides
  • Thyropropic acid (51-26-3) and its salts
  • Thyrothricine (1404-88-2)
  • Tiratricol (51-24-1)
  • Tolboxane (2430-48-8)
  • Tolbutamide (64-77-7)
  • Tolnaftate (2398-96-1)
  • Toluene-2,4-diamine (95-80-7)
  • Toluidines (26915-12-8), their isomers, salts and halogenated and sulfonated derivatives, except 4-hydroxy-2-nitro-toluidine and hydroxyethyl-2-nitro-p-toluidine
  • Toxins
  • Tranylcypromine (155-09-9) and its salts
  • Tretamine (51-18-3)
  • Tretinoin (retinoic acid) (302-79-4)
  • Triamterene (396-01-0) and its salts
  • Tribromoethanol (75-80-9)
  • Tribromosalicylanilide (1322-38-9)
  • Trichlormethine (817-09-4) and its salts
  • Trichloroacetic acid (76-03-9)
  • Trichloronitromethane (76-06-2)
  • Triclosan (3380-34-5)
    • Permitted at concentrations equal to or less than 0.03% in mouthwash and 0.3% in other cosmetic products.
    • All triclosan-containing products must meet the following conditions:
      1. chlorinated dibenzodioxin and dibenzofuran (PCDD/PCDF) impurities must not be present in quantities exceeding those described as follows:
        1. the concentration of the impurities, 2,3,7,8-tetra-chlorodibenzo-p-dioxin and 2,3,7,8-tetra chlorodibenzofuran, must not exceed 0.1 ng/g.
        2. the total concentration of all other PCDD/PCDF impurities must not be greater than 10 ug/g, with no individual impurity greater than 5 ug/g.
      2. the labels of oral cosmetics shall carry statements to the effect: "The product is not to be used by children under the age of 12, in the case of mouthwashes, avoid swallowing"; and
      3. manufacturers must provide the following:
        1. raw material specifications for triclosan;
        2. identification of the method of analysis used to determine the levels of PCDD's and PCDF's in triclosan;
        3. finished product specifications; and
        4. copy of product labelling
  • Tricresyl phosphate (tritolyl phosphate) (1330-78-5)
  • Trifluperidol (749-13-3)
  • N,N,N-Trimethyloxiranemethanamonium chloride (495403-02-6) with Siloxanes and Silicones, 3-[(2-aminoethyl)amino]-2-methylpropyl Me, di-Me, reaction products
    • For concentrations exceeding 4%, the company must submit a skin sensitization study and other data requirements to Environment Canada's New Substances Program at least 90 days prior to the manufacture of the product, as per Significant New Activity Notice No. EAU-153 under the Canadian Environmental Protection Act's New Substances Notification Regulations, November 13, 2004.
  • 3,6,10-Trimethyl-3,5,9-undecatrien-2-one (1117-41-5)
  • Triparanol (78-41-1)
  • Tripelennamine (91-81-6)
  • Tuaminoheptane (123-82-0), its isomers and salts
  • Urea (57-13-6)
    • Permitted at concentrations equal to or less than 10%.
  • Urea (carbamide) peroxide (124-43-6) (see peroxide and peroxide generating compounds)
  • Uriginea scilla Stern. and its galenical preparations
  • Vaccines
  • Valnoctamide (4171-13-5)
  • Veratrine (62-59-9), its salts and galenical preparations
  • Veratrum spp. and their preparations
  • Versalide (88-29-9)
  • Vinyl chloride monomer (27-39-8)
  • Warfarin (81-81-2) and its salts
  • Xanthinol (2530-97-4)
  • Xylidines (1300-73-8), their isomers, salts and, halogenated and sulfonated derivatives.
  • Xylometazoline (526-36-3) and its salts
  • Yohimbine (146-48-5) and its salts
  • Zinc peroxide (1314-22-3) (see peroxide and peroxide generating compounds)
  • Zirconium (7440-67-7) and its compounds, except the complexes, zirconium lakes, salts and pigments of zirconium colouring agents
    • Aluminum zirconium chloride hydroxide complexes AlxZr(OH)yClz and aluminum zirconium chloride hydroxide glycine complex are permitted only in deodorants in concentrations equal to or less than 25%, as anhydrous aluminum zirconium chloride and equal to or less than 5.45% as zirconium. The ratio of the number of aluminum atoms to that of the zirconium atoms must be between 2 and 10. The ratio of the number of (Al + Zr) atoms to that of the chlorine atoms must be between 0.9 and 2.1.
    • The inner label and the outer label of the cosmetic shall carry a cautionary statement to the effect: "Do not apply to irritated or damaged skin".
    • Not permitted in aerosol dispensers.
  • Zoxazolamine (61-80-3)